Substance Details

CAS Registry Number: 216974-75-3

CA Index Name: Immunoglobulin G1, anti-(human vascular endothelial growth factor) (human-mouse monoclonal rhuMAb-VEGF γ1-chain), disulfide with human-mouse monoclonal rhuMAb-VEGF light chain, dimer


Sequence Strand: 1334, 453, 453, 214, 214
1:  EVQLVESGGG LVQPGGSLRL SCAASGYTFT NYGMNWVRQA PGKGLEWVGW
51:  INTYTGEPTY AADFKRRFTF SLDTSKSTAY LQMNSLRAED TAVYYCAKYP
101:  HYYGSSHWYF DVWGQGTLVT VSSASTKGPS VFPLAPSSKS TSGGTAALGC
151:  LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS VVTVPSSSLG
201:  TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP
251:  PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
301:  QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR
351:  EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT
401:  PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS
451:  PGK

1:  EVQLVESGGG LVQPGGSLRL SCAASGYTFT NYGMNWVRQA PGKGLEWVGW
51:  INTYTGEPTY AADFKRRFTF SLDTSKSTAY LQMNSLRAED TAVYYCAKYP
101:  HYYGSSHWYF DVWGQGTLVT VSSASTKGPS VFPLAPSSKS TSGGTAALGC
151:  LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS VVTVPSSSLG
201:  TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP
251:  PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
301:  QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR
351:  EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT
401:  PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS
451:  PGK

1:  DIQMTQSPSS LSASVGDRVT ITCSASQDIS NYLNWYQQKP GKAPKVLIYF
51:  TSSLHSGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YSTVPWTFGQ
101:  GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV
151:  DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG
201:  LSSPVTKSFN RGEC

1:  DIQMTQSPSS LSASVGDRVT ITCSASQDIS NYLNWYQQKP GKAPKVLIYF
51:  TSSLHSGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YSTVPWTFGQ
101:  GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV
151:  DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG
201:  LSSPVTKSFN RGEC


Sequence Notes:
Type Location Description
bridge CYS-232 CYS-232' disulfide bridge
bridge CYS-235 CYS-235' disulfide bridge
bridge CYS-226 CYS-214'' disulfide bridge
bridge CYS-226' CYS-214''' disulfide bridge
bridge CYS-96 CYS-22 disulfide bridge
bridge CYS-150 CYS-206 disulfide bridge
bridge CYS-327 CYS-267 disulfide bridge
bridge CYS-431 CYS-373 disulfide bridge
bridge CYS-96' CYS-22' disulfide bridge
bridge CYS-206' CYS-150' disulfide bridge
bridge CYS-327' CYS-267' disulfide bridge
bridge CYS-431' CYS-373' disulfide bridge
bridge CYS-88'' CYS-23'' disulfide bridge
bridge CYS-194'' CYS-134'' disulfide bridge
bridge CYS-88''' CYS-23''' disulfide bridge
bridge CYS-194''' CYS-134''' disulfide bridge


Chemical Structure:

216974-75-3:Immunoglobulin G1, anti-(human vascular endothelial growth factor) (human-mouse monoclonal rhuMAb-VEGF γ1-chain), disulfide with human-mouse monoclonal rhuMAb-VEGF light chain, dimer

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